羟基红花黄色素A对缺血性脑卒中神经保护作用及机制的研究进展

刘环环, 李瑞青, 高静, 袁洁, 苏凯奇, 冯晓东

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (10) : 773-778.

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中国药学杂志
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中国药学杂志 ›› 2022, Vol. 57 ›› Issue (10) : 773-778. DOI: 10.11669/cpj.2022.10.001
综述

羟基红花黄色素A对缺血性脑卒中神经保护作用及机制的研究进展

  • 刘环环1, 李瑞青1,2,3, 高静1,2,3, 袁洁1, 苏凯奇1, 冯晓东1,2*
作者信息 +

Research Progress on the Neuroprotective Mechanism of Hydroxysafflor Yellow A on Ischemic Stroke

  • LIU Huan-huan1, LI Rui-qing1,2,3, GAO Jing1,2,3, YUAN Jie1, SU Kai-qi1, FENG Xiao-dong1,2*
Author information +
文章历史 +

摘要

缺血性脑卒中是因血管栓塞导致局部脑血流急剧减少或中断引起的脑组织缺血缺氧损伤,常伴有严重的神经功能障碍。羟基红花黄色素A是活血化瘀药红花的主要成分之一。现代药理学研究发现,它在缺血性心脑血管疾病中发挥神经保护作用可缓解缺血再灌注造成的各种损伤,但其发挥作用的具体机制仍不清楚。通过检索红花在脑卒中应用的相关文献,笔者就羟基红花黄色素A在缺血性脑卒中发挥保护作用的机制包括抗氧化应激、抑制神经炎症反应、抗细胞凋亡、保护血脑屏障及促进突触可塑性等方面进行综述。以期为羟基红花黄色素A作为神经保护药物在脑卒中的临床应用中提供理论支持。

Abstract

Ischemic stroke is the ischemia and hypoxia damage of brain tissue caused by the rapid decrease or interruption of local cerebral blood flow caused by vascular embolism, and it is often accompanied by severe neurological dysfunction. Hydroxysafflor yellow A is one of the main components of safflower, a medicine for promoting blood circulation and removing blood stasis. Modern pharmacological studies have found that it exerts a neuroprotective effect in ischemic cardiovascular and cerebrovascular diseases and can alleviate various injuries caused by ischemia-reperfusion, but the specific mechanism of its action is still unclear. By searching the relevant literatures about the application of safflower yellow in stroke, this article discusses the mechanism of hydroxysafflor yellow A in ischemic stroke including anti-oxidative stress, inhibition of neuroinflammatory response,anti-apoptosis,and protecting the blood-brain barrier and the promotion of synaptic plasticity are reviewed. It is expected to provide theoretical support for the clinical application of hydroxysafflor yellow A as a neuroprotective drug in stroke.

关键词

羟基红花黄色素A / 缺血性脑卒中 / 神经保护

Key words

hydroxysafflor yellow A / ischemic stroke / neuroprotection

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刘环环, 李瑞青, 高静, 袁洁, 苏凯奇, 冯晓东. 羟基红花黄色素A对缺血性脑卒中神经保护作用及机制的研究进展[J]. 中国药学杂志, 2022, 57(10): 773-778 https://doi.org/10.11669/cpj.2022.10.001
LIU Huan-huan, LI Rui-qing, GAO Jing, YUAN Jie, SU Kai-qi, FENG Xiao-dong. Research Progress on the Neuroprotective Mechanism of Hydroxysafflor Yellow A on Ischemic Stroke[J]. Chinese Pharmaceutical Journal, 2022, 57(10): 773-778 https://doi.org/10.11669/cpj.2022.10.001
中图分类号： R96   

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基金

国家自然科学基金项目资助(U2004131, 82174473, 82104973);河南省科技攻关项目资助(212102311117,222102310715)
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